Participants were 1417 students (51.7% male mean age 13.83 years, SD = 1.48) recruited from one high school in Hunan province, China. This study examined the relationship between anxiety sensitivity and irritability among youth, and further explored three possible mediated factors: selective attention for threat, delayed reward discounting, and insomnia. However, the psychological mechanisms of irritability are understudied. Child irritability is associated with higher risk of suicide and adulthood mental health problems. Irritability is common in multiple psychiatric disorders and is hallmark of disruptive mood dysregulation disorder.